It’s time to polish your physique: Strip the body fat and reveal the muscularity you’ve earned through years of brutal and focused effort. Just as you left no stone unturned in filling out and balancing your frame with quality muscle, you’ll only accept the best nutritional tools when it comes to attaining the extraordinary leanness that displays your physique at its finest. That’s exactly what you’ve found in Thermo Burn.
What can I expect from Thermo Burn?
Thermo Burn takes a three-fold approach to turbo-charge your efforts to absolutely and utterly demolish body fat. We’ve created a trilogy of synergistic supplement combinations to control appetite and enhance mood, improve subjective feelings of “energy” and, of course, promote thermogenesis and thus body fat oxidation:
-
-
- Appetite Control: Theacrine, cocoa extract and alpha GPC
- Energy Elevation: Caffeine and Rhodiola rosea
- Thermogenesis: Cayenne pepper fruit extract and bioperine
-
Thermo Burn: Appetite Control
The Appetite Control blend focuses on improving mood, controlling your appetite and bolstering your energy levels over the long haul of your fat-loss diet.
Thermo Burn contains what may be the “cleanest” over-the-counter “stimulant” of them all: Theacrine (as 125mg of TeaCrine® per dose). Theacrine improves mood, focus, subjective feelings of energy, and motivation to exercise, but actually decreases anxiety. Even after months of daily use (300mg), TeaCrine® does not lose its effectiveness or hook you into a nasty habit [which often happens with caffeine] . [On the other hand, co- administering TeaCrine® with caffeine (see below) may actually prevent de- sensitization.]
To synergize with TeaCrine®, we’ve also included 275mg of Chocamine®, a cocoa extract standardized with mood-boosting theobromine. [While Chocamine® may owe its mood altering effects to its methylxanthine content, cocoa extract has additional health benefits that stem from to its anti-oxidant and anti-flammatory properties.] Like theacrine, theobromine also blocks the adenosine receptor and Chocamine® may synergistically stimulate fat oxidation in combination with L-leucine [the essential amino acid you certainly shouldn’t skimp on when dieting down] .
To keep your cognitive powers even more on point, we’ve included 50mg of Alpha-Glyceryl Phosphoryl Choline (Alpha GPC from AlphaSize®) in each serving. Alpha GPC provides substrate for synthesis of the neurotransmitter acetylcholine, enhances memory and learning in animals, and may treat a variety of cognitive disorders. While the acute effects of choline supplementation may not be obvious, don’t give up on it. Chronic supplementation (~1 week or so) may improve cognition and even enhance strength (neurologically). (Can you imagine getting both “smarter” and stronger the longer you diet?…)
Thermo Burn: Energy Elevation
Naturally, we’ve included perhaps the world’s most popular energy booster in the form of caffeine [caffeine anhydrous (100 mg) and dicaffeine malate (as Infinergy™; 34 mg] . Caffeine has a wide variety of ergogenic effects and is both thermogenic, and lipolytic, making it a viable staple for any fat loss regimen. The small dose of theobromine in Chocamine® (see above) might also counterbalance caffeine’s hypertensive (blood pressure elevating) effect and synergize with caffeine to promote arousal.
Rhodiola rosea is an emerging adaptogen with revered anti-fatigue and ergogenic actions. Two daily doses of Thermo Burn deliver 130mg of Rhodiola rosea extract (≥3% total Rosavins and ≥1% Salidrosides), enough to significantly reduce mental fatigue and improve cognitive performance and sense of well-being when life’s stresses seem overwhelming. Take it from some of the most cognitively stressed people on the planet: Physicians working night shifts and medical students enduring exams.
Thermo Burn: Thermogenesis
To spice up your metabolism in a way you may never have, we’ve included cayenne pepper (Capsicum Annum) fruit extract (as 50mg Capsimax® per dose). The capsaicinoids in Capsimax® act via receptors in the brain to fire up the sympathetic nervous system. This elevates metabolic rate via thermogenesis and may even promote the development of new brown fat cells, a form of energy dissipating adipose tissue that exists in humans. Even the small amount of Capsimax™ (100mg total) in the recommended two daily doses of Thermo Burn is enough to increase lipolysis both at rest and during exercise.
When it comes to many dietary supplements, bioavailabilty (absorption) is the name of the game. Thus, Thermo Burn contains 2.5mg of Bioperine®, a black pepper extract containing 95+% piperine [which itself may even be thermogenic] . By inhibiting p-glycoprotein’s actions and preventing glucoronidation in the gut, piperine diminishes the intestinal barrier for many substances and makes them more lipid soluble (and thus able to traverse lipid membranes). Indeed, piperine has a good record of increasing bioavailability of drugs and supplements, including curcumin, beta-carotene, resveratrol, iron, selenium and CoQ10.
Whats the suggested dosage for Thermo Burn?
Take 1 capsule daily. After assessing your tolerance, you may take up to 2 capsules daily.
Research and References
Ziegenfuss TN, Habowski SM, Sandrock JE, Kedia AW, Kerksick CM, Lopez HL. A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine(R)) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters. Journal of dietary supplements. 2016:1-15.
Taylor L, Mumford P, Roberts M, et al. Safety of TeaCrine®, a non- habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. Journal of the International Society of Sports Nutrition. 2016;13(1):2.
Spriet LL. Exercise and Sport Performance with Low Doses of Caffeine. Sports Medicine. 2014;44(2):175-184.
Pohler H. Caffeine Intoxication and Addiction. The Journal for Nurse Practitioners. 2010;6(1):49-52.
Lopez HL, Wells S, Ziegenfuss TN. Theacrine-based supplement and method of use thereof. Google Patents; 2014.
Mumford GK, Evans SM, Kaminski BJ, et al. Discriminative stimulus and subjective effects of theobromine and caffeine in humans. Psychopharmacology (Berl). 1994;115(1):1-8.
Baggott MJ, Childs E, Hart AB, et al. Psychopharmacology of theobromine in healthy volunteers. Psychopharmacology (Berl). 2013;228(1):109-118.
Judelson DA, Preston AG, Miller DL, Munoz CX, Kellogg MD, Lieberman HR. Effects of theobromine and caffeine on mood and vigilance. J Clin Psychopharmacol. 2013;33(4):499-506.
Smit HJ, Gaffan EA, Rogers PJ. Methylxanthines are the psycho- pharmacologically active constituents of chocolate. Psychopharmacology (Berl). 2004;176(3-4):412-419.
Katz DL, Doughty K, Ali A. Cocoa and chocolate in human health and disease. Antioxidants & redox signaling. 2011;15(10):2779-2811.
Haytowitz DB, Bhagwat S. USDA Database for the Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods, Release 2. 2010; http://www.orac-info- portal.de/download/ORAC_R2.pdf, 2016.
Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem. 2004;52(12):4026-4037.
Feduccia AA, Wang Y, Simms JA, et al. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacol Biochem Behav. 2012;102(2):241-248.
Smit HJ. Theobromine and the pharmacology of cocoa. Handb Exp Pharmacol. 2011(200):201-234.
Bruckbauer A, Zemel MB. Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirtuin-Mediated Metabolism in Muscle Cells and Adipocytes. PLoS One. 2014;9(2):e89166.
Phillips SM. A Brief Review of Higher Dietary Protein Diets in Weight Loss: A Focus on Athletes. Sports Medicine. 2014;44(2):149-153.
Traini E, Bramanti V, Amenta F. Choline alphoscerate (alpha-glyceryl- phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent. Curr Alzheimer Res. 2013;10(10):1070-1079.
Lippelt DP, van der Kint S, van Herk K, Naber M. No Acute Effects of Choline Bitartrate Food Supplements on Memory in Healthy, Young, Human Adults. PLoS One. 2016;11(6):e0157714.
Parker AG, Byars A, Purpura M, Jäger R. The effects of alpha- glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Journal of the International Society of Sports Nutrition. 2015;12(1):P41.
Naber M, Hommel B, Colzato LS. Improved human visuomotor performance and pupil constriction after choline supplementation in a placebo-controlled double-blind study. Scientific reports. 2015;5:13188.
Bellar D, LeBlanc NR, Campbell B. The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength. Journal of the International Society of Sports Nutrition. 2015;12(1):42.
Fredholm BB. Notes on the history of caffeine use. Handb Exp Pharmacol. 2011(200):1-9.
Weinberg BA, Bealer BK. The world of caffeine: the science and culture of the world’s most popular drug. Psychology Press; 2001.
Glade MJ. Caffeine-Not just a stimulant. Nutrition. 2010;26(10):932-938.
Helms ER, Aragon AA, Fitschen PJ. Evidence-based recommendations for
natural bodybuilding contest preparation: nutrition and supplementation. Journal of the International Society of Sports Nutrition. 2014;11(1):1-20.
Belza A, Toubro S, Astrup A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur J Clin Nutr. 2007;63(1):57-64.
Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double- blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am J Clin Nutr. 1990;51(5):759- 767.
Mitchell ES, Slettenaar M, vd Meer N, et al. Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure. Physiol Behav. 2011;104(5):816-822.
van den Bogaard B, Draijer R, Westerhof BE, van den Meiracker AH, van Montfrans GA, van den Born B-JH. Effects on Peripheral and Central Blood Pressure of Cocoa With Natural or High-Dose Theobromine. A Randomized, Double-Blind Crossover Trial. 2010;56(5):839-846.
Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001;6(3):293-302.
Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011;18(4):235-244.
Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2000;7(5):365-371.
Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double- blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2000;7(2):85-89.
Saito M, Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol. 2013;24(1):71-77.
Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite. 2012;59(2):341-348.
Ludy MJ, Moore GE, Mattes RD. The Effects of Capsaicin and Capsiate on Energy Balance: Critical Review and Meta-analyses of Studies in Humans. Chem Senses. 2012;37(2):103-121.
Saito M. Brown adipose tissue as a regulator of energy expenditure and body fat in humans. Diabetes Metab J. 2013;37(1):22-29.
Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009;58(7):1526-1531.
Wu J, Bostrom P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150(2):366-376.
Sharp LZ, Shinoda K, Ohno H, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One. 2012;7(11):e49452.
Lee P, Swarbrick MM, Zhao JT, Ho KK. Inducible brown adipogenesis of supraclavicular fat in adult humans. Endocrinology. 2011;152(10):3597- 3602.
Bloomer RJ, Canale RE, Shastri S, Suvarnapathki S. Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study. Lipids in health and disease. 2010;9:72-72.
Westerterp-Plantenga M, Diepvens K, Joosen AM, Berube-Parent S, Tremblay A. Metabolic effects of spices, teas, and caffeine. Physiol Behav. 2006;89(1):85-91.
O’Connor A, Corbin KD, Nieman DC, Swick AG. A randomized, controlled trial to assess short-term black pepper consumption on 24-hour energy expenditure and substrate utilization. Functional Foods in Health and Disease. 2013;3(10):377-388.
Han Y, Chin Tan TM, Lim L-Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol Appl Pharmacol. 2008;230(3):283-289.
Singh J, Dubey RK, Atal CK. Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content. J Pharmacol Exp Ther. 1986;236(2):488-493.
Deferme S, Augustijns P. The effect of food components on the absorption of P-gp substrates: a review. J Pharm Pharmacol. 2003;55(2):153-162.
Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-356.
Badmaev V, Majeed M, Norkus EP. Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Nutr Res. 1999;19(3):381-388.
Johnson JJ, Nihal M, Siddiqui IA, et al. Enhancing the bioavailability of resveratrol by combining it with piperine. Mol Nutr Food Res. 2011;55(8):1169-1176.
Vuppala KK. An Evaluation of Bioavailability Enhancement of Organic Elemental Iron with BioPerine® in Rabbits. International Journal of Pharmacy and Pharmaceutical Research 2016;5(4):72-79.
Badmaev V, Majeed M. Selenium: a quest for better understanding. Alternative Therapies. 1996;4(2):59-66.
Badmaev V, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem. 2000;11(2):109-113.
Arnaud MJ. Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handb Exp Pharmacol. 2011(200):33-91.
Hellum BH, Tosse A, Hoybakk K, Thomsen M, Rohloff J, Georg Nilsen O. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med. 2010;76(4):331-338.
van Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann K. Inhibition of monoamine oxidase and acetylcholinesterase by Rhodiola rosea L. Planta Med. 2008;74(09):PA202.
Reviews
There are no reviews yet